Advancing AUD Treatment: Our Research Priorities
The Naltrexone Alliance supports cutting-edge research to improve the efficacy, accessibility, and clinical adoption of Naltrexone for Alcohol Use Disorder. This page provides an overview of our research priorities, data resources, and opportunities for scientific collaboration.
Practice Support
Practice Support
Practice Support
Areas of Scientific Investment
We support research that accelerates Naltrexone discovery, improves clinical deployment, and expands precision treatment approaches.
Personalized Medicine
Identifying pharmacogenetic or phenotypic biomarkers that predict individual response to Naltrexone (e.g., OPRM1 gene and others).
Implementation Science
Studies focused on integrating Naltrexone initiation and management into non-specialty settings (e.g., EDs, primary care, inpatient units).
Novel Dosing & Delivery
Clinical trials evaluating alternative formulations (e.g., nasal) or non-daily dosing protocols for increased patient adherence and preference.
Combination Therapies
Research exploring the synergistic effects of Naltrexone when combined with other pharmacotherapies (e.g., Naltrexone + Varenicline) or specific psychosocial interventions.
Research Tools
Research Tools
Research Tools
Access Data, Measures & Collaboration Resources
01
Alliance Data Registry
A de-identified dataset from partner clinics supporting observational and retrospective research.
02
Symposium Archive
Presentations, abstracts, and key findings from the Annual Research Symposium.
03
Validated Measures Library
AUD assessment tools: AUDIT-C, craving scales, time-to-heavy-drinking-day, and other validated endpoints.
04
Funding Opportunities
Information on RFP cycles, pilot grants, and mechanisms for early-career investigators.
Literature
Literature
Literature
Key Publications & Emerging Evidence
Core Meta-Analyses
Links to foundational reviews demonstrating Naltrexone efficacy in reducing relapse and heavy-drinking days.
Recent High-Impact Papers
Summaries of influential studies from the last 12–18 months.
Call for Papers
Information on collaborative review articles and Alliance-sponsored special issues.
Collaboration
Collaboration
Collaboration
Join the Alliance Research Network
Become part of a collaborative community of investigators focused on advancing Naltrexone science. Receive priority updates on new datasets, funding cycles, and symposium announcements.
Blog
Blog
Blog
Helpful Tools to Get Started
Explore expert tips, health news, and patient-friendly articles to guide your wellness journey
Safety
Safety
Safety
A Note on Opioid Use
Naltrexone is an opioid antagonist.
If you take opioid pain medications or have Opioid Use Disorder, you must be opioid-free for a period before starting Naltrexone — otherwise it may trigger sudden withdrawal.
This site focuses specifically on Alcohol Use Disorder (AUD).
FAQ
Frequently Asked Questions
Clear, straightforward answers to common concerns patients and families have about Naltrexone.
What does naltrexone do?
Does naltrexone make you sick if you drink?
Is naltrexone addictive?
Can I start naltrexone even if I’m not ready to quit drinking?
What forms does it come in?
How long does treatment last?
FAQ
Frequently Asked Questions
Clear, straightforward answers to common concerns patients and families have about Naltrexone.
What does naltrexone do?
Does naltrexone make you sick if you drink?
Is naltrexone addictive?
Can I start naltrexone even if I’m not ready to quit drinking?
What forms does it come in?
How long does treatment last?
FAQ
Frequently Asked Questions
Clear, straightforward answers to common concerns patients and families have about Naltrexone.
What does naltrexone do?
Does naltrexone make you sick if you drink?
Is naltrexone addictive?
Can I start naltrexone even if I’m not ready to quit drinking?
What forms does it come in?
How long does treatment last?